WHO label Lineage + additional mutations Country first detected (community) Spike mutations of interest Year and month first detected Impact on transmissibility Impact on immunity Impact on severity Transmission in EU/EEA Omicron BA.2 South Africa (y) November 2021 Increased (v) (1, 2) Increased (v) (3) Reduced (v) (4, 5) Community Omicron BA.4 South Africa L452R, F486V, R493Q January 2022 No evidence Increased (6, 7) No evidence Community Omicron BA.5 South Africa L452R, F486V, R493Q February 2022 No evidence Increased (6, 7) Unclear (8) Dominant y: G142D, N211I, Δ212, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K All sub-lineages of the listed lineages are also included in the variant Variants of Interest (VOI) For these variants, evidence is available on genomic proper...
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